Understanding the DNA Fragmentation Index and Its Clinical Relevance

1. Introduction

• DNA fragmentation testing provides insights beyond standard semen analysis.

• The DNA Fragmentation Index (DFI) quantifies sperm DNA damage.

2. Measuring DNA Fragmentation with SCD

• SCD method exposes sperm DNA to reagents, producing halos in healthy cells.

• Fragmented DNA remains condensed, enabling accurate DFI measurement.

3. Clinical Importance of DFI

• High DFI is associated with reduced fertilization potential.

• Predicts embryo quality and ART success rates.

4. Patient Assessment

• Men with unexplained infertility.

• Recurrent ART failures or miscarriage history.

• Patients exposed to environmental or lifestyle risk factors.

5. Benefits of China Suppliers

• Certified, high-quality kits for clinical and research use.

• Affordable pricing supports widespread laboratory adoption.

• OEM and private-label options for clinic branding.

6. Research Applications

• Enables investigation of oxidative stress and genetic integrity.

• Supports development of therapies to improve sperm DNA quality.

7. Conclusion

• Understanding and measuring DFI is critical for male fertility assessment.

• Using reliable China-sourced SCD kits ensures accurate, cost-effective diagnostics.